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. 2021 Jun 15;131(12):e145859. doi: 10.1172/JCI145859

Figure 4. IFN-γ, compared with TNF, alters the chromatin landscape in a stimulus-specific manner.

Figure 4

(A) Examples of hyperaccessible peaks upon cytokine stimulation. (B) Total number of hyper- and hypoaccessible peaks called for each listed comparison. U, undifferentiated at baseline; D, differentiated at baseline. (C) PCA of peaks differentially hyperaccessible from baseline after cytokine treatment. (D) K-means clustered heatmap of induced ATAC-Seq peaks across any stimulation condition for differentiated and undifferentiated melanomas (subcolumns are in the order 0 hour, IFN-γ, and TNF for each cell line). (E) Motif enrichment of IFN-γ– compared with TNF-induced genes. bZIP, basic leucine zipper domain; RHD, rel homology domain. (F) Top divergent GO terms of nearby genes for IFN-γ– versus TNF-specific peaks.