Figure 6. Differentiated and undifferentiated cell lines respond to cytokine stimulation with differences in inferred activity of both signal-dependent and lineage-determining transcription factors.

(A and B) VIPER analysis showing inferred transcription factor activity for baseline differentiated versus undifferentiated cell lines following (A) TNF or (B) IFN-γ exposure. Regulators such as PRDM1, HMGA1, and SOX9 had high inferred activity only in the baseline differentiated group.