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. 2021 Jun 15;131(12):e145859. doi: 10.1172/JCI145859

Figure 8. Enrichment of IFN-γ–induced dedifferentiation gene signatures in melanomas correlates with the response to anti–PD-1 and better overall survival.

Figure 8

(A) Enrichment of the dedifferentiation signature in the paired pre- and post-treatment biopsies (n = 68) from responders and nonresponders in the CheckMate 038 biopsy cohort. (B) Enrichment of the dedifferentiation signature in the baseline biopsies from the CheckMate 038 biopsy cohort, including the paired and unpaired biopsies (n = 101), from responders and nonresponders. (C) Correlation of baseline enrichment of the dedifferentiation signature (Sig) with overall survival in TCGA melanoma data set. med, medium.