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Changes in fIVIM with tumor growth. fIVIM increases with the proliferation of neovascularity in some tumors. As the pseudo-diffusion coefficient associated with blood microcirculation is much larger than the true diffusion coefficient in tissues, fast-decaying signal (IVIM effect) appears at low b-values. fIVIM, the flowing blood fraction, increases with the proliferation of neovascularity in some tumors.
