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. 2020 Oct 22;28(6):649–666. doi: 10.1038/s41417-020-00246-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Stimulation of B cells with NHL-a101 and NHL-a102 vp17s induces the activation of several signaling molecules involved in promoting cell survival, cell proliferation, cell cycle progression, G1/S and G2/M phase transition. STRING database and literature data mining were used to identify known and experimentally verified interactions. The several kinases involved in the pathway are represented by diamonds, the other proteins by ellipses. The proteins represented in cyan are the ones activated by both NHL-a101 and NHL-a102. The molecules activated by NHL-a101 are in magenta, the ones stimulated by NHL-a102 in yellow. PI3K: phosphatidylinositol-3-kinase; Akt: protein kinase B; CDK1: cyclin-dependent kinase 1; ABL1: tyrosine-protein kinase ABL1; CDK2: cyclin-dependent kinase 2; CDK4: cyclin-dependent kinase 4; CDK6: cyclin-dependent kinase 6; CHEK1: serine/threonine-protein kinase Chk1; CHEK2: serine/threonine-protein kinase Chk2; EGFR: epidermal growth factor receptor; eIF-2A: interferon-induced, double-stranded RNA-activated protein kinase; hMSH2: DNA mismatch repair protein Msh2; JAK-1: tyrosine-protein kinase JAK1; MAPK 8: mitogen-activated protein kinase 8; NPM: nucleophosmin; p53: cellular tumor antigen p53; PTP-1B: tyrosine-protein phosphatase non-receptor type 1; RAC1: ras-related C3 botulinum toxin substrate 1; RAF1: tyrosine-protein kinase JAK1; Rb: Retinoblastoma-associated protein; STAT1: signal transducer and activator of transcription 1-alpha/beta.