. 2021 Jun 14;11:12432. doi: 10.1038/s41598-021-90434-w

Table 1.

Histological evaluation of hearts and pancreata in saline, wt CVB3, pBRCVB3, Mt 2, Mt 3, Mt 4, Mt 8, and Mt 10-infected mice.

Parameters	Saline	wt CVB3	pBRCVB3	Mt 2	Mt 3	Mt 4	Mt 8	Mt 10
Heart
Incidence	0/9 (0.0)	10/10 (100.0)	8/10 (80.0)	0/9 (0.0)	2/9 (22.0)	3/9 (33.3)	1/16 (6.3)	0/9 (0.0)
Mortality	0/9 (0.0)	10/10 (100.0)	2/10 (20.0)	0/9 (0.0)	0/9 (0.0)	1/9 (11.1)	0/16 (0.0)	0/9 (0.0)
Myocardial lesions	0.0 (0.0)^a	34.2 ± 13.4	11.8 ± 7.3	0.0 (0.0)^a	0.2 ± 0.1^a	0.4 ± 0.3^a	0.1 ± 0.1^a	0.0 (0.0)^a
Pancreas
Incidence	0/9 (0.0)^a	10/10 (100.0)	10/10 (100.0)	8/9 (88.8)	9/9 (100.0)	5/9 (55.5)	5/16 (31.2)^b	0/9 (0.0)^a
Atrophy	0 (0.0)^a	10/10 (100.0)	9/10 (90.0)	8/9 (88.8)	9/9 (100.0)	5/9 (55.5)	1/16 (6.3)^a	0 (0.0)^a
Inflammation	0 (0.0)^a	10/10 (100.0)	10/10 (100.0)	8/9 (88.8)	9/9 (100.0)	5/9 (55.5)	5/16 (31.2)^b	0 (0.0)^a
Necrosis	0 (0.0)^a	9/10 (90.0)	8/10 (80.0)	4/9 (44.4)	6/9 (66.6)	3/9 (33.3)^b	0/16 (0.0)^a	0 (0.0)^a
Mineralization	0 (0.0)^a	8/10 (80.0)	7/10 (70.0)	3/9 (33.3)^b	6/9 (66.6)	2/9 (22.2)^b	0/16 (0.0)^a	0 (0.0)^a

() Indicates percentages.

^aDenotes significant differences in comparison with wt CVB3 and pBRCVB3 group (p < 0.001).

^bDenotes significant differences in comparison with wt CVB3 and pBRCVB3 group (p < 0.05).