Table 2.

Mean difference to human and p-values of the gene expression calculated with ANOVA of healthy, transiently inflamed and constantly inflamed tenocytes of the four animal model species.

			SCX	TNC	TNM	COL1	COL3	COL5	MMP1	MMP3	MMP13	IL6	COX2	NFKB	P53	ALP	FAK
Healthy	Mouse	Diff	2.65	− 0.74	− 1.05	− 3.03	2.54	− 2.17	− 9.34	9.45	8.50	4.65	9.40	− 0.20	− 0.30	3.14	− 0.25
		Adj p	0.230	0.811	0.951	0.038	0.122	0.609	0.064	0.002	0.000	0.005	0.000	0.999	0.961	0.032	0.995
	Rat	Diff	5.28	2.84	− 1.37	3.95	3.80	4.62	− 2.97	10.24	5.24	0.54	11.30	3.00	4.47	1.85	4.72
		Adj p	0.008	0.014	0.882	0.008	0.015	0.067	0.851	0.001	0.013	0.978	0.000	0.053	0.000	0.287	0.000
	Sheep	Diff	2.39	3.79	− 3.52	− 7.91	− 0.50	0.41	− 4.71	9.12	9.47	− 0.16	13.61	− 0.72	− 0.36	− 0.14	3.95
		Adj p	0.313	0.002	0.201	0.000	0.981	0.998	0.539	0.003	0.000	1.000	0.000	0.931	0.927	1.000	0.001
	Horse	Diff	1.49	− 0.24	− 3.11	− 4.72	0.41	1.71	− 2.93	1.94	5.37	− 3.67	15.65	3.79	3.52	− 1.11	2.11
		Adj p	0.711	0.996	0.296	0.002	0.991	0.780	0.857	0.793	0.012	0.022	0.000	0.014	0.000	0.720	0.055
Transient inflammation	Mouse	Diff	− 1.22	− 0.69	− 2.59	− 2.62	− 3.06	− 3.07	1.23	− 5.08	− 4.96	− 4.02	− 4.15	− 1.24	− 0.59	0.46	− 0.46
		Adj p	0.515	0.870	0.048	0.177	0.017	0.010	0.984	0.011	0.001	0.001	0.000	0.180	0.803	0.990	0.963
	Rat	Diff	− 2.94	− 1.42	− 2.85	− 2.93	− 4.43	− 3.57	− 0.66	− 3.22	− 1.56	− 0.98	− 4.84	− 0.01	− 0.34	− 1.54	− 1.48
		Adj p	0.019	0.342	0.029	0.114	0.001	0.004	0.999	0.124	0.412	0.537	0.000	1.000	0.967	0.563	0.299
	Sheep	Diff	− 0.59	− 0.20	0.59	− 0.12	− 1.84	− 1.49	0.39	− 6.54	− 4.19	− 2.83	− 6.20	− 0.52	0.16	1.38	1.31
		Adj p	0.930	0.998	0.937	1.000	0.189	0.291	1.000	0.002	0.004	0.007	0.000	0.841	0.998	0.651	0.404
	Horse	Diff	− 0.77	1.44	− 0.34	1.40	− 0.36	− 0.95	3.97	− 0.32	0.15	3.25	− 6.63	− 0.16	1.38	2.22	0.98
		Adj p	0.840	0.330	0.992	0.691	0.989	0.671	0.498	0.999	1.000	0.003	0.000	0.997	0.152	0.249	0.658
Constant inflammation	Mouse	Diff	− 1.23	− 0.51	− 3.33	− 1.89	− 3.30	− 2.52	1.64	− 4.82	− 3.41	− 4.54	− 3.96	− 1.33	− 0.09	2.83	0.22
		Adj p	0.911	0.949	0.166	0.361	0.003	0.501	0.977	0.014	0.209	0.021	0.094	0.586	1.000	0.093	0.998
	Rat	Diff	− 3.27	− 1.76	− 4.86	− 3.80	− 7.16	− 5.29	4.75	− 1.96	3.26	1.13	− 1.71	0.13	0.18	− 1.09	− 1.35
		Adj p	0.238	0.177	0.028	0.020	0.000	0.039	0.509	0.490	0.241	0.866	0.727	1.000	0.999	0.797	0.412
	Sheep	Diff	− 2.01	− 0.63	− 1.41	0.56	− 1.81	− 2.94	1.51	− 6.73	− 2.93	− 0.42	− 7.68	− 0.18	0.19	1.24	1.48
		Adj p	0.653	0.900	0.822	0.975	0.111	0.366	0.983	0.001	0.328	0.996	0.002	1.000	0.999	0.719	0.333
	Horse	Diff	− 3.10	2.28	− 1.74	1.37	− 0.39	− 2.04	3.59	− 0.24	1.49	5.53	− 8.36	− 0.63	0.95	3.18	0.58
		Adj p	0.280	0.059	0.693	0.637	0.972	0.679	0.733	1.000	0.839	0.006	0.001	0.949	0.678	0.054	0.932

Significant p-values (Tukey HSD correction, p<0.05) and the matching mean differences in gene expression to humans are indicated in bold.