Table 3.

Subgroup analyses according to comorbid of liver disease.

Variable	Multivariable Cox model	P-value
	Hazard ratio (95% CI)
Liver disease group (n = 85,087)
AST (model 1)
Normal	1
Mild elevation	1.15 (0.91, 1.44)	0.246
Moderate elevation	2.23 (1.80, 2.76)	< 0.001
Severe elevation	4.56 (3.19, 6.53)	< 0.001
ALT (model 2)
Normal	1
Mild elevation	0.97 (0.74, 1.27)	0.820
Moderate elevation	1.67 (1.34, 2.08)	< 0.001
Severe elevation	3.19 (2.12, 4.79)	< 0.001
AST/ALT ratio (model 3)	1.01 (1.00, 1.03)	0.157
γ-GTP (model 4)
Normal	1
Mild elevation	1.41 (1.13, 1.77)	0.003
Moderate elevation	2.22 (1.61, 3.06)	< 0.001
Severe elevation	2.45 (1.85, 3.25)	< 0.001
dAAR (model 5)	1.15 (1.12, 1.18)	< 0.001
No Liver disease group (n = 427,659)
AST (model 1)
Normal	1
Mild elevation	1.06 (0.94, 1.20)	0.358
Moderate elevation	1.82 (1.56, 2.12)	< 0.001
Severe elevation	3.52 (2.45, 5.07)	< 0.001
ALT (model 2)
Normal	1
Mild elevation	1.08 (0.93, 1.26)	< 0.333
Moderate elevation	1.49 (1.27, 1.76)	< 0.001
Severe elevation	2.94 (1.96, 4.41)	< 0.001
AST/ALT ratio (model 3)	1.03 (1.02, 1.04)	< 0.001
γ-GTP (model 4)
Normal	1
Mild elevation	1.37 (1.20, 1.57)	< 0.001
Moderate elevation	1.58 (1.23, 2.03)	< 0.001
Severe elevation	2.28 (1.85, 2.81)	< 0.001
dAAR (model 5)	1.11 (1.09, 1.13)	< 0.001

CI, confidence interval; AST, aspartate transaminase; ALT, alanine aminotransferase; γ-GTP, γ-glutamyl transpeptidase.