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. 2021 Jun 14;7:142. doi: 10.1038/s41420-021-00531-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — A Immunohistofluorescence staining of ZO-1, occludin, and claudin-5 expression in vivo. Frozen slices (10 μm thick) of the corpus striatums from APP/PS1 + shNC, APP/PS1 + shKhdrbs2, and APP/PS1 + shHey2 groups were stained with CD31 (green), TJPs (red), and DAPI (blue). Scale bar represents 100 μm. B Quantification of pixel intensity. (n = 5) C The effects of Khdrbs2 knockdown or Hey2 knockdown on APP/PS1 brain microvessels. Data are presented as mean ± SD (n = 3). *P < 0.05 versus APP/PS1 + shNC group, **P < 0.01 versus APP/PS1 + shNC group. D The schematic illusion of interactions between ACTBP2, KHDRBS2, and HEY2 in Aβ1–42-incubated ECs.