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. 2021 Jun 14;11:12487. doi: 10.1038/s41598-021-91792-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Layout of the interactive chemogenomic web application. Selecting a compound of interest from the drop-down list (red circle), will allow one to explore (left panel) its fitness profile, GO enrichment profile, individual gene fitness profile (cofitness) or cluster analysis of all the compounds in our screens. Compounds were saved with their final concentration and the date (yy/mm/dd) when the count matrices were performed e.g. NDMA_674.9µM_190801. To allow for custom visualizations, the user can adjust thresholds for FDR and fitness scores. Image is a screenshot from the web application.