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. 2021 Jun 14;11:12487. doi: 10.1038/s41598-021-91792-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Hierarchical cluster analysis of the all 22 chemogenomic screens. Pearson correlation was used to generate the “coinhibitory” square matrix and Ward was used as the distance. Branch colors on the two identical dendrogram indicate the three major clusters. Compounds within each cluster are highly correlated as indicated by the color scale as well as the dendrogram height and may correspond to compounds that have similar chemogenomic profiles and therefore may suggest similar mechanism of action. For example, the fitness profiles for NDEA all cluster tighter as expected (orange dendrogram branch color). Globally, two of the three major clusters (orange and navy branches in dendrogram) that include NDMA, NDEA, DMF and formamide exhibit significant correlation (visualized as darker red region in the heatmap). This finding is consistent with the chemogenomic profile similarity between these compounds, all of which were enriched for the genes involved in the arginine biosynthetic pathway. Figure was generated using the Bioconductor v3.12, https://www.bioconductor.org/.