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. 2021 Jun 14;11:12487. doi: 10.1038/s41598-021-91792-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fitness profiles showing genes (via deletion strains) affected by nitrosamines and related compounds. Genes (arranged alphabetically) are plotted on the horizontal axis versus their corresponding fitness defect (FD) scores on the vertical axis. Sensitive strains have a positive FD score, while resistant strains have a negative FD score. (A) Sensitive strains affected by NDMA include those lacking ARG1, ARG3, GCN4, LIP5, AIM26 etc. (B) Genes affected by NDEA (via effect on their deletion strains) are PEP12, ARG3, SNF1, BRO1, among others. (C) CSG2, SUR1, ILV1, PMT2 etc. have their deletion strains affected by NMBA. (D) DMF was sensitive to strains lacking the following genes ARG3, GCN4, ORT1, SNF8 etc. The concentration at which the compound was screened is indicated. Not all strains (genes) with significant FD scores are labelled. Fitness profiles were generated using the Bioconductor v3.12, https://www.bioconductor.org/.