Fig. 2. Between-endotype differences in clinical variables, virus, nasopharyngeal microbiome, and nasopharyngeal metabolome data in infants with respiratory syncytial virus bronchiolitis.

To visualize the between-endotype differences, the clinical variables and viruses are treated as numeric variables and processed by autoscaling. The microbiome data (20 most abundant species) are processed by log₂ transformation and autoscaling. The metabolome data (20 metabolites with the highest normalized mutual information score) are processed by log₂ transformation with batch effect adjustment and autoscaling. RSV respiratory syncytial virus, IFN interferon, IL interleukin, sIgE specific immunoglobulin E.