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. 2021 Jun 14;12:3601. doi: 10.1038/s41467-021-23859-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Chord diagram showing major clinical variables by endotype. The ribbons connect from the individual endotypes to the major clinical and virus characteristics. The width of the ribbon represents the proportion of infants within the endotype who have the corresponding clinical or virus characteristic. Then, it was scaled to a total of 100%. For example, the endotype B infants (light red) had a high proportion of parental asthma, IgE sensitization, and coinfection with rhinovirus. Endotype C (light orange) infants had a high proportion of lifetime antibiotics use and positive pressure ventilation use during the index hospitalization for bronchiolitis. b Venn diagram of three major clinical variables (parental history of asthma, IgE sensitization, rhinovirus infection) and their intersections. The Venn diagram illustrates the composition of three major clinical variables and their intersections. The numbers correspond to the number of infants in each subset and intersection. c Upset plot corresponding to the presented Venn diagram. The plot illustrates the composition of three major clinical variables and their intersections visualized based on the four endotypes. Vertical stacked bar charts reflect the number of infants within each subset and intersection colored according to the endotypes. Horizontal bars indicate the number of infants in each clinical variable set. Black dots indicate the sets of subsets and intersections; connecting lines indicate relevant intersections related to each stacked bar chart.