Table 1.

Comparison of dosing, duration, adverse events, and efficacy of desensitization and sustained unresponsiveness for oral immunotherapy (OIT), epicutaneous immunotherapy (EPIT), and sublingual immunotherapy (SLIT)

	OIT	EPIT	SLIT
Route of administration	Oral (ingestion)	Epicutaneous (applied on the skin)	Sublingual (under the tongue)
Foods	Peanut, tree nuts	Peanut	Peanut, tree nuts
Most commonly used daily dose	300 mg	250 μg	2–7 mg
Approximate time* to achieve initial desensitization	6–12 months	2–3 years	2–3 years
Desensitization efficacy	High	Small to moderate	Small to moderate
Adverse events	Local: frequent Anaphylaxis: infrequent	Local: frequent Anaphylaxis: rare	Local: frequent Anaphylaxis: rare
Sustained unresponsiveness	Variable	Not evaluated	Not evaluated
Quality of life post-intervention	Improved	Improved	Not evaluated

* Varies between different research studies