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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: J Rheumatol. 2020 Dec 15;48(7):985–991. doi: 10.3899/jrheum.201128

Figure 3. RA-associated expression among RA women who worsened during pregnancy.

Figure 3.

Volcano plots showing differential expression between RA women who worsened during pregnancy (RAworsened) and healthy women before and during pregnancy. (A) At pre-pregnancy (T0), 429 genes were differentially expressed (q<0.05; fold-change (FC)≥2) between RAworsened and healthy women, consisting of some that were over-expressed in RA (maroon dots) and some that were under-expressed (purple dots). (B) At the 3rd trimester (T3), when RA worsened, 207 of the 429 genes (48%) were no longer differentially expressed (maroon and purple dots with −1≤log2(FC)≤1 and –log10(q-value)<1.3). Numerous genes (green dots) became newly differentially expressed at T3 when disease activity worsened.