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. 2020 Dec 15;17(7):1085–1096. doi: 10.1002/alz.12249

FIGURE 2.

FIGURE 2

Amyloid beta (Aβ)‐cortical thickness relationships depended on tau. A) Global PiB DVR predicting cortical thickness in FTP– subjects (n = 89), adjusted for age and sex, yielded only positive significant associations in illustrated ROIs. B) Across all regions of interest (ROIs), global PiB DVR negatively predicted cortical thickness in FTP+ subjects (n = 36), adjusted for age and sex, in the illustrated ROIs. C) Generalized linear models of PiB DVR predicting fusiform thickness, adjusted for age and sex , stratified by FTP status (FTP– in green; FTP+ in red; Braak III/IV threshold  >1.26 SUVR) showed a significant positive relationship in FTP– subjects (r = 0.211, P = .047) and a significant negative relationship in FTP+ subjects (r = –0.360, P = .031). There was a significant global PiB DVR by FTP status interaction (P = .002) across all subjects. Correlations between global PiB DVR and cortical thickness did not survive correction for multiple comparisons. DVR, distribution volume ratio; FTP, flortaucipir; PiB, Pittsburgh compound B; SUVR, standardized uptake value ratio