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. 2021 Jun 14;11:12465. doi: 10.1038/s41598-021-91937-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of RGS4 inhibition on I_KACh kinetics in db/db SAN myocytes. (A) Representative I_K recordings illustrating peak and desensitized responses to CCh (10 µM) in wildtype and db/db SAN myocytes pre-treated with the RGS4 inhibitor CCG-4986 (10 µM). (B) Time course of CCh stimulated I_KACh, measured at − 100 mV, in wildtype and db/db SAN myocytes in the presence of CCG-4986. (C) Summary of peak I_KACh at − 100 mV in wildtype and db/db SAN myocytes in the presence of CCG-4986. (D) Summary of I_KACh desensitization in wildtype and db/db SAN myocytes in the presence of CCG-4986. (E) Summary of I_KACh recovery time during CCh washout in wildtype and db/db SAN myocytes in the presence of CCG-4986. For panels (C–E) n = 16 wildtype and 18 db/db SAN myocytes; data analyzed by Student’s t-test.