Figure 5.

Effect of somatotroph-selective GHSR deletion on plasma acyl-ghrelin, GH secretion, rebound hyperphagia, and blood glucose following a 24-h fast. (A) Plasma acyl-ghrelin and (B) plasma GH in fed mice and after a 24-h fast. (C) Rebound food intake at different time points following a 24-h fast. (D) Blood glucose in fed mice and after a 24-h fast. All the data were analyzed using repeated-measures two-way ANOVA followed by Sidak's multiple comparisons test. All the values are expressed as mean ± SEM. n = 6–11 (for A, B, and D) and n = 7–10 (for C).∗P < 0.05, ∗∗P < 0.001, ∗∗∗P < 0.001, and ∗∗∗∗P < 0.0001 for significant changes or ns = no significant changes.