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. 2021 Jun 1;8:685648. doi: 10.3389/fnut.2021.685648

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Copyright © 2021 Zhu, Fogelholm, Larsen, Poppitt, Silvestre, Vestentoft, Jalo, Navas-Carretero, Huttunen-Lenz, Taylor, Stratton, Swindell, Kaartinen, Lam, Handjieva-Darlenska, Handjiev, Schlicht, Martinez, Seimon, Sainsbury, Macdonald, Westerterp-Plantenga, Brand-Miller and Raben.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Trial flow diagram. *A total of 2,224 individuals participated and 556 were randomized to the HP-MI group, but one of them withdrew consent and requested data deletion. HP-MI, high protein-low glycemic index diet, moderate intensity physical activity; HP-HI, high protein-low glycemic index diet, high intensity physical activity; MP-MI, moderate protein-moderate glycemic index diet, moderate intensity physical activity; MP-HI, moderate protein-moderate glycemic index diet, high intensity physical activity.