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Schematic representation of the radiation-induced NF-κB signaling network. The activation of NF-κB is mediated by different stimuli: (A) the EGFR signaling pathway, especially through the activity of HER2; (B) the radiation-induced cytokines; and (C) DSBs generated by IR-induced ROS. The transcriptional program of NF-κB leads to several downstream events, which result in enhanced aggressiveness, increased survival and better fitness of cancer cells.
