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. 2021 Jun 1;11:662840. doi: 10.3389/fonc.2021.662840

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Copyright © 2021 Galeaz, Totis and Bisio

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Activators and effectors of NRF2 signaling pathway following IR exposure. (A, B) KEAP1-dependent activation of NRF2: IL-6 induces an increase in the phosphorylated form of p62, which combines with the NRF2 inhibitor KEAP1, leading to the release and translocation of NRF2 into the nucleus (A); (B) evidence of mTORC1 involvement in p62 phosphorylation. (C) A putative KEAP1-independent mechanism of NRF2 activation. (D) Canonical transcriptional targets of NRF2; (E) NRF2-mediated regulation of NOTCH1 signaling.