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. 2021 Jun 1;11:683057. doi: 10.3389/fonc.2021.683057

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Copyright © 2021 Fountzilas, Kotoula, Koliou, Liontos, Papadopoulou, Giannoulatou, Papanikolaou, Tikas, Chrisafi, Mauri, Chatzopoulos, Fostira, Pectasides, Oikonomopoulos, Aivazi, Andrikopoulou, Visvikis, Aravantinos, Zagouri and Fountzilas

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis was performed in patients with high-grade serous ovarian cancer. (A) Progression-free survival (PFS) and (B) Overall survival (OS) based on the presence of pathogenic variants in HRR and/or TP53 genes. (C) PFS and (D) OS based on the presence of clonal pathogenic variants in HRR and/or TP53 genes. (E) Forest plot of hazard ratios showing the risk of death for patients with HRR and/or TP53 clonal pathogenic variants upon adjustment for clinicopathological parameters. *Statistically significant parameters.