. 2021 Jun 1;11:683057. doi: 10.3389/fonc.2021.683057

Table 2.

Cox regression analysis with respect to OS and PFS in patients with HRR and/or TP53 pathogenic variants.

	Univariate				Multivariate*
		Event/Total	HR (95% CI)	p-value	Event/Total		HR (95% CI)	p-value
Entire cohort with HRR and/or TP53 pathogenic variants-excluding mucinous tumors	OS
	Pathogenic variants			0.023				0.23
	HRR only	21/39	0.54 (0.34-0.87)	0.012	21/39		0.69 (0.43-1.12)	0.14
	TP53 only	128/196	0.77 (0.59-1.01)	0.058	125/188		0.83 (0.63-1.10)	0.19
	Both	89/114	Reference	–	88/111		Reference	–
	Clonal pathogenic variants			0.016				0.091
	HRR only	18/38	0.45 (0.27-0.78)	0.004	18/36		0.55 (0.32-0.94)	0.030
	TP53 only	142/210	0.84 (0.61-1.15)	0.27	138/201		0.83 (0.60-1.15)	0.25
	Both	53/69	Reference	–	53/69		Reference	–
	PFS**
	Pathogenic variants			0.036				0.19
	HRR only	24/39	0.56 (0.36-0.88)	0.012	24/39		0.67 (0.42-1.05)	0.081
	TP53 only	145/186	0.83 (0.64-1.08)	0.16	140/179		0.86 (0.66-1.12)	0.26
	both	92/112	Reference	–	91/110		Reference	–
	Clonal pathogenic variants			0.055				0.16
	HRR only	22/37	0.56 (0.34-0.93)	0.023	22/36		0.62 (0.38-1.03)	0.063
	TP53 only	160/201	0.95 (0.70-1.30)	0.75	154/193		0.93 (0.68-1.27)	0.63
	Both	54/68	Reference	–	54/68		Reference	–
Advanced HGSOC	OS
	Pathogenic variants			0.10					0.31
	HRR only	19/29	0.61 (0.37-1.02)	0.057	19/29	0.75 (0.45-1.26)			0.28
	TP53 only	102/146	0.79 (0.58-1.06)	0.12	101/141	0.81 (0.59-1.09)			0.17
	Both	74/91	Reference	–	73/90	Reference
	Clonal pathogenic variants			0.023				0.044
	HRR only	13/26	0.42 (0.23-0.78)	0.006	13/26		0.47 (0.25-0.87)	0.016
	TP53 only	116/161	0.84 (0.59-1.19)	0.32	114/155		0.75 (0.53-1.07)	0.11
	Both	44/55	Reference	–	44/55		Reference	–
	PFS**
	Pathogenic variants			0.23	–
	HRR only	22/29	0.69 (0.43-1.10)	0.12
	TP53 only	114/142	0.83 (0.62-1.11)	0.21
	Both	76/90	Reference	–
	Clonal pathogenic variants			0.088				0.17
	HRR only	17/26	0.55 (0.31-0.96)	0.037	17/26		0.58 (0.33-1.02)	0.058
	TP53 only	129/157	0.94 (0.67-1.33)	0.74	125/151		0.85 (0.60-1.21)	0.37
	Both	44/54	Reference	–	44/54		Reference	–

HR, hazard ratio; CI, confidence interval; HRR, homologous recombination repair; HGSOC, high-grade serous ovarian cancer; PFS, progression-free survival; OS, overall survival.

*Adjusting for age and performance status.

**Assessed in patients treated with 1^st line chemotherapy.

Statistically significant p-values are shown in bold.