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. 2021 Jun 1;12:685237. doi: 10.3389/fimmu.2021.685237

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Copyright © 2021 Looney, Lorenc, Halushka and Karakousis

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Genes that are both differentially methylated and differentially expressed are involved in immune cell functioning and are subject to regulation by candidate miRNAs. (A) Genes that were both differentially methylated and differentially expressed were selected and used for gene ontology biological process (GO : BP) functional enrichment analysis. -Log₁₀ (adjusted p-value) value for each GO : BP term is reported to the right of each bar. GO : BP terms related to immune cell activation are highlighted in red. Those related to exocytosis and secretion are highlighted in blue. (B) Genes that were both differentially methylated and differentially expressed were compared to genes that we found to be differentially expressed and targeted by at least one candidate miRNA. Overlap represents the number of genes that are differentially expressed by RNAseq, targets of one or more miRNA candidate, and differentially methylated.