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. 2021 Jun 1;12:685237. doi: 10.3389/fimmu.2021.685237

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Copyright © 2021 Looney, Lorenc, Halushka and Karakousis

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DMRs DEGs and DE miRNA targets intersect at the AMPK signaling pathway. Genes that were differentially methylated, differentially expressed, or targeted by candidate miRNAs were subjected to functional enrichment KEGG analysis. These genes were most significantly associated with the AMPK signaling pathway. Genes which are only differentially methylated are highlighted in cyan. Genes which are only differentially expressed are highlighted in red. Genes which are differentially methylated, differentially expressed, and regulated by one or more miRNA are highlighted in purple. Light green boxes represent other pathway genes that were not found to be significantly in our studies.