Table 2.
Hazard ratios of hospital admission within 1-14 days for patients with S-gene target failure (SGTF) variants compared with those without SGTF variants
| SGTF status by age group | No (%) admitted to hospital | Stratified base model*—hazard ratio (95% CI): SGTF v non-SGTF | Absolute risk model† | |
|---|---|---|---|---|
| Hazard ratio (95% CI): SGTF v non-SGTF | Absolute risk of 14 day hospital admission—% (95% CI) | |||
| Base model | ||||
| Overall: | ||||
| SGTF | 27 710/592 409 (4.7) | 1.52 (1.47 to 1.57) | 1.51 (1.47 to 1.55) | 4.7 (4.6 to 4.7) |
| Non-SGTF | 8523/246 869 (3.5) | 1.00 (reference) | 1.00 (reference) | 3.5 (3.4 to 3.5) |
| Age group specific model | ||||
| <10 years: | ||||
| SGTF | 288/31 935 (0.9) | 0.93 (0.70 to 1.25) | 0.97 (0.79 to 1.20) | 0.9 (0.8 to 1.0) |
| Non-SGTF | 121/12 281 (1.0) | 1.00 (reference) | 1.00 (reference) | 1.0 (0.8 to 1.2) |
| 10-19 years: | ||||
| SGTF | 472/63 084 (0.7) | 1.21 (0.99 to 1.49) | 1.18 (1.00 to 1.39) | 0.7 (0.7 to 0.8) |
| Non-SGTF | 209/30 646 (0.7) | 1.00 (reference) | 1.00 (reference) | 0.7 (0.6 to 0.8) |
| 20-29 years: | ||||
| SGTF | 2149/115 296 (1.9) | 1.29 (1.16 to 1.43) | 1.30 (1.19 to 1.42) | 1.9 (1.8 to 1.9) |
| Non-SGTF | 707/45 561 (1.6) | 1.00 (reference) | 1.00 (reference) | 1.5 (1.4 to 1.7) |
| 30-39 years: | ||||
| SGTF | 3964/118 229 (3.4) | 1.45 (1.34 to 1.58) | 1.41 (1.32 to 1.51) | 3.4 (3.3 to 3.5) |
| Non-SGTF | 1216/47 341 (2.6) | 1.00 (reference) | 1.00 (reference) | 2.6 (2.4 to 2.7) |
| 40-49 years: | ||||
| SGTF | 5162/102 684 (5.0) | 1.61 (1.50 to 1.74) | 1.59 (1.50 to 1.69) | 5.0 (4.9 to 5.2) |
| Non-SGTF | 1429/41 581 (3.4) | 1.00 (reference) | 1.00 (reference) | 3.4 (3.3 to 3.6) |
| 50-59 years: | ||||
| SGTF | 6734/93 468 (7.2) | 1.58 (1.48 to 1.69) | 1.58 (1.50 to 1.67) | 7.2 (7.0 to 7.4) |
| Non-SGTF | 1902/38 743 (4.9) | 1.00 (reference) | 1.00 (reference) | 4.9 (4.7 to 5.1) |
| 60-69 years: | ||||
| SGTF | 4733/44 709 (10.6) | 1.65 (1.53 to 1.79) | 1.63 (1.53 to 1.73) | 10.6 (10.3 to 10.9) |
| Non-SGTF | 1361/19 188 (7.1) | 1.00 (reference) | 1.00 (reference) | 7.1 (6.8 to 7.5) |
| 70-79 years: | ||||
| SGTF | 2653/15 726 (16.9) | 1.45 (1.32 to 1.60) | 1.49 (1.38 to 1.60) | 16.9 (16.3 to 17.5) |
| Non-SGTF | 932/7477 (12.5) | 1.00 (reference) | 1.00 (reference) | 12.5 (11.7 to 13.2) |
| ≥80 years: | ||||
| SGTF | 1555/7278 (21.4) | 1.60 (1.41 to 1.82) | 1.50 (1.36 to 1.64) | 21.7 (20.7 to 22.7) |
| Non-SGTF | 646/4051 (15.9) | 1.00 (reference) | 1.00 (reference) | 16.2 (15.0 to 17.3) |
Hazard ratios from primary stratified models estimated on basis of Cox regression stratified by potential confounders 10 year age group, sex, ethnicity, index of multiple deprivation (IMD) fifth, region of residence, and week of specimen collection and using regression adjustment for quantitative covariates age, IMD rank, and date of specimen.
Secondary absolute risk model based on Cox regression stratified by SGTF status and age group only and regressed on remaining potential confounders. 14 day absolute hospital admission risks by SGTF status estimated on basis of absolute risk model, at mean levels of potential confounders.