Table 4.
Citrullination in T1D.
| Target proteins | Affected immune responses | References |
|---|---|---|
| GAD65 | target of autoreactive T cells | (12, 13, 17) |
| (HLA-A2 and HLA-DRB1*04:01) | ||
| IAPP | target of autoreactive cells | (17, 127, 161) |
| (HLA-DR and HLA-DQ8) | ||
| IA-2 | potential target of autoreactive T cells | (13) |
| (HLA-A2) | ||
| GRP78 | target of autoreactive T cells | (15–17) |
| (HLA-DRB1*04:01) | ||
| recognized by autoantibody | ||
| IGRP | potential target of autoreactive T cells | (13) |
| (HLA-A2) |
GAD65, glutamic acid decarboxylase 65; IAPP, islet amyloid polypeptide; IA-2, islet antigen-2; GRP78, glucose-regulated protein 78; IGRP, islet-specific glucose-6-phosphatase catalytic subunit-related protein.