TABLE 2.

Clinical implications of Rab GTPases in cancer.

Rab GTPase	Cancer types	Expression	Clinical implications	References
Rab1a	Tongue Breast Prostate Liver Lung Stomach Colorectum	Increased	Poor prognosis	Cheng et al., 2019; Shao et al., 2019a,b
Rab1b	Breast	Decreased	Good prognosis	Jiang et al., 2015
Rab2	Pancreas Breast	Increased	Poor prognosis	Luo et al., 2015; Jin et al., 2018
Rab5a	Lung Liver Breast Ovarian Glioma	Increased	Poor prognosis	Frittoli et al., 2014; Jian et al., 2020
Rab7	Melanoma Lung Stomach	Increased	Poor prognosis	Alonso-Curbelo et al., 2014; Liu et al., 2020; Xiao and Schmid, 2020
Rab10	Liver	Increased	Poor prognosis	Wang W. et al., 2017
Rab11 Rab11a	Colorectum Lung	Increased	Poor prognosis	Chung et al., 2016; Dong et al., 2017
Rab13	Stomach	Increased	Poor prognosis	Chen et al., 2019
Rab21	Pancreas	Increased	Poor prognosis	Anand et al., 2020
Rab25	Breast Ovarian Kidney Lung Stomach Liver Bladder Glioma Prostate	Increased	Poor prognosis	Wang S. et al., 2017
	Colorectum Esophagus Head and neck	Decreased	Poor prognosis Good prognosis	Nam et al., 2010; Wang S. et al., 2017
Rab27a	Liver	Increased	Poor prognosis	Guerra et al., 2019
	Colorectum Prostate	Decreased	Good prognosis	Dong et al., 2015; Worst et al., 2017
Rab27b	Bladder Breast Liver	Increased	Poor prognosis	Hendrix et al., 2010; Zhang et al., 2012; Ostenfeld et al., 2014; Binenbaum et al., 2018; Madeo et al., 2018; Guerra et al., 2019
	Prostate	Decreased	Good prognosis	Worst et al., 2017
Rab37	Lung	Increased	Poor prognosis	Tsai et al., 2014
Rab40b	Stomach	Increased	Poor prognosis	Li et al., 2015