Table II.
Treatment planning and dose delivery.
| Author, year | Target definition | Median GTV (range), ml | Dose prescription | Median dose, Gy/fractions | Dose range, Gy | Median BED10Gy (range) | (Refs.) |
|---|---|---|---|---|---|---|---|
| Shen et al, 2017 | PTV: GTV + 5 mm | NR | 100% isodose line to cover | 45/3-5 | 36-54 | 85.5 (72.0-124.8) | (15) |
| GTV 95% isodose line to cover PTV | |||||||
| Weiner et al, 2016 | PTV: GTV + 5 mm | 107.0 (16.9-625.9)a | 95% isodose line to cover 95% PTV | 55/5 | 40-55 | 99.0 (72.0-115.5) | (16) |
| Klein et al, 2015 | PTV: GTV + 5 mm | NR | NR | NR/6 | 24-60a | NRS | (17) |
| Jung et al, 2014 | PTV: ITV + 2-4 mm | 40.0 (5.0-1287.0) | 70-80% isodose line (Cyber Knife) 92-99% isodose line to cover 95% PTV (Rapid Arc) | 45/3-5b EBRT + SBRT boost, 16/1 | 30-60b EBRT + SBRT boost, 15-18 | 86.0 (48.0-150.0) | (18) |
| Sebastian et al, 2019 | NR | NR | NR | 45/5 | 40-50 | NR | (19) |
| Kozak et al, 2020 | PTV: ITV + 2-3 mma | NR | NR | 40/5 | 26-50a | NR | (20) |
aFor the whole population included in the analysis;
b91% SBRT only, 9% EBRT + SBRT boost. BED, biologically effective dose; EBRT, external beam radiation therapy; GTV, gross tumour volume; ITV, internal target volume; NR, not reported; NRS, not reported separately; PTV, planning target volume; SBRT, stereotactic body radiation therapy.