Figure 3.

Behavioral effects of rimonabant mediated by brain CB₁R are similar in wild-type and βArr2-KO mice. (a) Hyperambulatory activity induced by 3 mg/kg rimonabant in drug-naïve mice, as quantified by beam disruption in an x–y box; (b) anxiogenic effect of rimonabant as tested in the elevated plus maze. Points or columns and vertical bars represent mean ± SEM from 4–6 experiments; *, significant difference (P < 0.05) from corresponding vehicle-treated group, as determined by 2-way ANOVA followed by Dunnett’s multiple comparisons test.