Figure 5.

Glycemic control of lean control mice and mice with high-fat diet induced obesity treated with vehicle or (S)-MRI-1891, as analyzed by hyperinsulinemic/euglycemic insulin clamps and described in the Supporting Information. Hepatic glucose production (a), glucose clearance or R_d (b), glucose infusion rate (c), and 2-deoxyglucose uptake into soleus muscle (d) were analyzed from data obtained from the clamp, as described in the Supporting Information. *, significant difference (P < 0.05) within the indicated groups, as determined by 2-way ANOVA followed by Dunnett’s multiple comparisons test. #, significant difference (P < 0.05) between wild-type and βArr-2 KO groups, as determined by 2-way ANOVA followed by Sidaks’s multiple comparisons test. Columns and vertical bars indicate mean ± SEM from 6–8 animals. For an explanation, see the text.