TABLE 4.
Outcomes measurement and adverse events in enrolled studies, and the evaluation of growth factors.
| Author/year | Outcomes result and measurement | Adverse events | Outcomes on molecular levels |
|---|---|---|---|
| Abaroa 2016 | Biopsy and photographs at week 12 | Not mentioned | Not mentioned |
| Alves 2016 | Global photographs and phototrichogram analysis (vertex, grontal, and occipital) | Not mentioned | Not mentioned |
| Alves 2018 | Global photographs and phototrichogram analysis (vertex, grontal, and occipital) | Not mentioned | Not mentioned |
| Anitua 2017 | Phototrichogram analysis using the TrichoScope ASG and the TrichoSciencePro hair and scalp diagnostic software, for women, mild scalp and crown region, hair density, hair diameterm terminal/vellus-like hair ratio and thin/regular/thick hair shafts among terminal follicles, and standardized global macrophotographs, self-assessment questionnaire and rated satisfaction following a likert scale, biosy from 6 volunteers, with ki-67 | Not mentioned | Measuring TGFβ1, PDGF-AB, EGF, VEGF, TSP-1 and Ang-1 increasing by ELISA |
| Bruce 2019 | TrichoScan analysis and TrichoScan digital image analysis, hair count, hair density, cumulative thickness. QOL questionaire | weeks 4,8 and 12 of PRP treatment | Not mentioned |
| Butt G 2020 | Macroscopic photographs, pull test, trichoscopic photomicrographs, physician glob asseement score (PhGAS), patient global assessment score (PaGAS), hair density | Not mentioned | Not mentioned |
| Butt G 2019 | Macroscopic photographs, pull test, trichoscopic photomicrographs, physician glob asseement score (PhGAS), patient global assessment score (PaGAS) | Not mentioned | Not mentioned |
| Dubin 2020 | Hair density, caliber and blinded global photographic assessment | In PRP, mild headache 50%, scalp tightness 50%, swelling29, redness 14%, post-injection bleeding 7%, and tingling 7% | Not mentioned |
| El-husseiny 2020 | Patients' global photographs, Lugwig's and Sinclair's grading, questionaire of satisfacition, improvement in hair density, hair quality and pain injection and infection | 11 headache, all reported mild pain during injections | No significant difference was found between the median concentrations (ng/L) of VEGF in both nonactivated and activated single- and double-spin prepared PRP measuring by ELISA |
| Garg 2017 | Parameters which were observed on video-microscopy are hair count, diameter of hair, change in texture, multiplicity of hair, perifollicular halo, perifollicular pigmentation, increase in telogen hair and increase in vellus hair count | Not mentioned | Not mentioned |
| Gentile a 2020 | Photography, physician's and patient's global assessment scale, and standardized phototrichograms | Not mentioned | Not mentioned |
| Gentile b 2020 | Hair density by trichoscan, bioposi on anti-ki-67, anti-CD31 | Not mentioned | Not mentioned |
| Gkini 2014 | Hair density and patients' satisfaction, hair-pull test, dermoscopic photomicrographs, macroscopic photographs and a satisfaction questionnaire | 25% mild pain after application, 60% scalo sensitivity | Not mentioned |
| Hausauer 2018 | Folliscope and global photography, hair count, hair density, shaft caliber, Norwood-Hamilton or ludwig scale were determined, patient's satisfiaction | Not mentioned | Not mentioned |
| Ho 2020 | Hair density and diameter using folliscope | Not mentioned | Not mentioned |
| Juhasz 2020 | Hair density | Not mentioned | Not mentioned |
| Kang 2014 | Phototrichogram scalp on hair numbers, thickness with follioscope | Not mentioned | Flow cytometry was performed using PRP preparation and an equal amount of peripheral blood in two healthy volunteers. One participant presented 6.7 cells ⁄ lL of CD34 + cells in peripheral blood, whereas those in the autologous PRP preparation were 31.1 cells ⁄ lL |
| Laird 2018 | Satisfaction | Not mentioned | Not mentioned |
| Lee 2015 | Hair density, hair count, hair thickness | Not mentioned | Western blot analyses of PDGF-A revealed significant differences between PRP-treated skin samples and control skin samples |
| Makki 2020 | Photographs, quartile grading scale with two dermatologists, hair parameters, and hair density, patients satisfaction | Local injection pain | Not mentioned |
| Paththinige 2018 | Hair density, hair count under dermoscopic photographs | Not mentioned | Not mentioned |
| Puig 2016 | Hair count through photography, hair mass index (measured using the cohen hair check system); and patient survery | Not mentioned | Not mentioned |
| Qu 2019 | Global macroscopic photographs, standardized phototrichograms, hair-pull test and satisfaction questionaire | Mild pain when injection, headache | Not mentioned |
| Rossano 2017 | Gene type | Not mentioned | It showed a negative correlation. IL-1a could be used as a prognostic value for PRP efficacy in female pattern hair loss |
| Schiavone 2018 | Photographs by global physician assessment (GPA) score and questionaires | Bruise after 48–72 h and spontaneously resolved in the fourth to fifth postop day | Not mentioned |
| Schiavone 2014 | Photographs by global physician assessment (GPA) score and questionaires | Not mentioned | Not mentioned |
| Sclafani 2014 | Hair density | No | Not mentioned |
| Shapiro 2020 | Hair density | No | Not mentioned |
| Siah 2020 | Dermatoscope, photography, hair density counting and hair caliber measurement | At week8, treatment site having a higher hair density 129.3 comparing to placebo site 115.3 | PDGF-BB was the highest concentration of growth factor injected, and VEGF was tested for the lowest growth factor concentration |
| Singhal 2015 | Hair count, hair thickness, hair root strength, and overall alopecia | 3 mild head pain | Not mentioned |
| Starace 2019 | Pull test, blobal photographs, and trichoscan, hair measurement | Not mentioned | Not mentioned |
| Takikawa 2011 | Histological exam | Not mentioned | Not mentioned |
| Tan 2019 | Folliscope, questionnaire | Not mentioned | Not mentioned |
| Tawfik 2018 | Hair growth, hair density, hair diameter, photography, hair-pull test, patient's satisfaction scale, standardized phototrichograms, and patient’s satisfaction | Not mentioned | Not mentioned |
| Zhang 2018 | Biopsy ki-67, hair density | Not mentioned | Not mentioned |
| Navarro 2015 | Trichogram, photograpy, anagen, telogen | Not mentioned | Not mentioned |
| DeVasconcelos 2015 | Mann-whitnety test | No | Not mentioned |
| Yang 2020 | Dermascopy and photograph | Not mentioned | Not mentioned |
| Zhang 2020 | Photographs, satisfaction questionaire | Not mentioned | Not mentioned |
| Zolfaghari 2020 | Hair number and thickness | Not mentioned | Measuring TGFβ1, TGFβ2, PDGF, EGF, VEGF, and HGF increasing by ELISA |