Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jun 14;22:220. doi: 10.1186/s12882-021-02433-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 1 — Renal biopsy findings. a Periodic acid-Schiff staining (40×), b periodic acid-methenamine silver staining (40×), c immunostaining for fibrinogen, and d electron microscopy findings (2,000×). Fifteen glomeruli (3 were completely hyalinized, and 12 were mostly hyalinized) exhibit evident crescent formation, with transitioning to fibrous crescents. The glomerular loops are collapsed and destroyed with fibrin deposition. Expansion of the mesangial matrix and an increase in the mesangial cell count are observed, although no double contours or spike formation of the glomerular basement membranes are observed. Lymphocyte infiltration is evident in the tubular interstitium, and 60–70 % of all renal tubules are atrophied. Moderate arteriosclerosis resulting from intimal thickening and medial atrophy is observed in the interlobular arteries (a, b). Immunofluorescence failed to detect the expression of IgG, IgA, IgM, C3, C4, or C1q, and only fibrinogen expression is observed in the crescents (c). Electron microscopy reveals no electron-dense deposits, and podocyte degeneration is observed with evident disappearance of the podocyte foot processes (d)