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. 2021 Jun 15;10:19. doi: 10.1186/s40035-021-00243-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Mitochondria of VPS35^D620N cells appear damaged under basal conditions and do not respond to CCCP. a, b Representative TEM micrographs of WT and VPS35^D620N (clones 1 and 2) cells treated with DMSO (a) or 10 μM CCCP for 6 h (b). Mitochondria are highlighted in red. DGC, degradative compartment; G, Golgi apparatus; PM, plasma membrane. Scale bar, 1 μm. c Representative examples of the mitochondria categories I–V. d Quantification of the mitochondrial profile of WT or VPS35^D620N (clones 1 and 2) cells treated with DMSO or 10 μM CCCP for 6 h. Statistical analyses were performed by two-way ANOVA followed by Tukey’s post-hoc test. n.s. non-significant, ****P < 0.001