Table 2.
Univariate and multivariate analyses of rRFS and OS in all patients after PSM
| Variable | rRFS | OS | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | |||||||||
| HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | |
| Initial hepatectomy stage data | ||||||||||||
| Age (≤45y vs >45y) | 0.914 | 0.464–1.799 | 0.794 | 1.463 | 0.440–4.870 | 0.535 | 1.484 | 0.508–4.335 | 0.470 | 5.437 | 0.434–8.173 | 0.189 |
| Gender (male vs female) | 1.398 | 0.549–3.556 | 0.482 | 0.669 | 0.232–1.928 | 0.457 | 4.647 | 0.622–34.730 | 0.134 | 0.622 | 0.113–3.417 | 0.585 |
| HBV-DNA (<500 vs ≥500 IU/ML) | 1.134 | 0.624–2.061 | 0.679 | 1.223 | 0.549–2.725 | 0.622 | ||||||
| AFP level (<200 vs ≥200ng/ml) | 1.570 | 0.844–2.920 | 0.154 | 0.629 | 0.245–1.614 | 0.335 | 1.266 | 0.545–2.941 | 0.583 | 0.282 | 0.081–0.986 | 0.048* |
| DCP median (mAU/ML) | 1.001 | 0.768–1.181 | 0.047* | 1.003 | 0.998–1.008 | 0.244 | 1.001 | 0.706–1461 | 0.458 | 1.094 | 0.546–4.098 | 0.654 |
| Blood loss (ml) | 1.001 | 0.999–1.002 | 0.336 | 1.000 | 0.998–1.002 | 0.829 | ||||||
| Indocyanine green (%) | 0.981 | 0.936–1.028 | 0.427 | 0.958 | 0.887–1.036 | 0.284 | ||||||
| Maximum tumor size (<3 vs ≥3cm) | 1.113 | 0.620–2.072 | 0.684 | 1.735 | 0.723–4.165 | 0.218 | ||||||
| Tumor number (single vs multiple) | 1.617 | 0.861–3.039 | 0.135 | 1.857 | 0.796–4.331 | 0.152 | ||||||
| Tumor capsule (complete vs incomplete) | 1.157 | 0.644–2.078 | 0.626 | 0.608 | 0.252–1.465 | 0.267 | ||||||
| Tumor margin (<1 vs ≥1cm) | 0.059 | 0.283–0.914 | 0.024* | 0.491 | 0.209–1.152 | 0.102 | 0.304 | 0.135–0.688 | 0.004* | 0.161 | 0.048–0.533 | 0.003* |
| Differentiation grade (I/II vs III/IV) | 0.810 | 0.411–1.597 | 0.542 | 1.161 | 0.484–2.784 | 0.739 | ||||||
| MVI (no vs yes) | 1.454 | 0.809–2.614 | 0.211 | 1.616 | 0.827–3.157 | 0.160 | 2.029 | 0.917–4.491 | 0.081 | 4.002 | 1.201–13.332 | 0.024* |
| 8th TNM stage (IA + IB vs II + IIIA) | 0.794 | 0.491–1.286 | 0.349 | 0.598 | 0.272–1.135 | 0.201 | 1.629 | 0.940–2.824 | 0.082 | 1.904 | 0.743–4.877 | 0.180 |
| Extent of liver resection (major vs minor) | 0.683 | 0.317–1.474 | 0.332 | 0.529 | 0.157–1.777 | 0.304 | ||||||
| Recurrent stage data | ||||||||||||
| AFP level (<200 vs ≥200ng/ml) | 1.934 | 0.988–3.786 | 0.054 | 1.128 | 0.416–3.060 | 0.813 | 3.198 | 1.369–7.467 | 0.007* | 0.385 | 0.095–1.566 | 0.182 |
| Maximum recurrent tumor size (<3 vs 3~5cm) | 5.806 | 2.224–15.158 | 0.000* | 3.237 | 0.682–15.396 | 0.139 | 4.282 | 1.429–12.837 | 0.009* | 2.454 | 0.424–14.213 | 0.317 |
| Recurrent tumor number (single vs multiple) | 1.743 | 0.873–3.479 | 0.115 | 3.137 | 0.754–13.051 | 0.116 | 1.284 | 0.444–3.714 | 0.644 | 6.702 | 0.677–18.080 | 0.104 |
| TTR (≤12 vs >12m) | 0.742 | 0.413–1.335 | 0.320 | 0.759 | 0.316–1.862 | 0.539 | 0.392 | 0.157–0.982 | 0.046* | 0.198 | 0.048–0.826 | 0.026* |
| Treatment strategy (repeat hepatectomy vs RFA) | 1.084 | 0.610–1.925 | 0.784 | 0.958 | 0.429–2.136 | 0.916 | 1.440 | 0.652–3.180 | 0.367 | 1.536 | 0.595–3.965 | 0.375 |
Abbreviations: AFP, α-fetoprotein; DCP, des-γ-carboxy-prothrombin; MVI, microvascular invasion; TTR, time to recurrence; RFA, radiofrequency ablation. *P < 0.05