Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jun 15;40:195. doi: 10.1186/s13046-021-01980-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 6 — TRIM37 promotes RCC tumorigenesis and metastatic potential in xenograft models. A, TRIM37 overexpression significantly promoted the tumor volume of subcutaneous model than NC group. B-C, TRIM37 overexpression significantly improved the tumor size and weight than NC group. D, The mice weights gradually improved in both NC and TRIM37 overexpression group. There is no statistical difference between two groups. E, compared to NC group, tumors in TRIM37-overexpression group displayed significantly enhancive Ki67 and PCNA expression, as well as upregulated ub-H2A and TGF-β1 levels. F, Overexpression of TRIM37 accelerated more RCC cells to metastasize to pulmonary foci compared with control group, accompanied with higher fluorescence signal. G, More pulmonary foci were visibly observed in TRIM37 overexpression group. H, Using clinical RCC samples, TRIM37, TGF-β1 and EMT markers (N-cadherin and Vimentin) were correlatively upregulated in metastatic sites than primary lesions. I, Immunoblot assay demonstrated higher TRIM37, TGF-β1 and EMT markers in metastatic lesions than primary lesions. J, Model depicting the mechanism by which TRIM37 orchestrates RCC progression via TGF-β1/Smad2/3 signaling under a histone H2A ubiquitination-dependent manner