Table 5.

Best gene–gene interaction models identified by GMDR

Interaction model	Training bal. acc	Testing bal. acc	P†	CV consistency
rs1801133	0.5487	0.5282	0.0547	9/10
rs2066470-rs1801131	0.5956	0.5929	0.0010	10/10
rs2274976-rs1801133-rs1801131	0.6232	0.5961	0.0010	5/10

GMDR generalized multifactor dimensionality reduction

^†Adjusted for maternal education, family income, residence location, abnormal pregnancy history, family consanguineous marriage history, family congenital malformation history, personal lifestyle and habit before pregnancy, exposure history to environmentally hazardous substances as well as medicine history in this pregnancy