Table 1.

The possible factors of EG damage in TBI coagulopathy

Factors	Types
Natriuretic peptide	ANP, BNP, CNP
Catecholamine	NE, Epi
Inflammatory mediators	TNF-α, IL-1β, IL-6, IL-8, IL-10
Angiopoietin	Ang-2
Chemotactic factors	fMLP
Reactive species	ROS, RNS
Histone deacetylase	HDAC
Extracellular proteases	MMP-1, MMP-2, MMP-7, MMP-9, MMP-14, MMP-16, ADAM-10, ADAM-15, ADAM-17 ADAMTS-1, ADAMTS-4 Heparanase, hyaluronidase, thrombin, plasmin, elastase, lysosomal cathepsin B, tryptase β

EG endothelial glycocalyx, TBI traumatic brain injury, ANP atrial natriuretic peptide, BNP brain natriuretic peptide, NE norepinephrine, Epi epinephrine, TNF tumor necrosis factor, IL interleukin, Ang angiopoietin, fMLP N-formylmethionyl-leucyl-phenylalanine, ROS reactive oxygen species, RNS reactive nitrogen species, HDAC histone deacetylase, MMP matrix metalloproteinase, ADAM a disintegrins and metalloproteinase, ADAMT a disintegrin and metalloproteinase with thrombospondin motif