Table 3.

Randomized Placebo Controlled Trials Investigating the Effect of Se Supplementation on Clinical Outcomes in Cervical Intraepithelial Neoplasia or Cervical and Uterine Cancer.

Author	Subjects	Intervention	Major results
Karamali et al, 2015 36	58 women with cervical intraepithelial neoplasia grade 1 (CIN1)	200 µg of Se (form: Se yeast), n = 26 Placebo, n = 26, Time: 6 months	Higher CIN1 regression
Muecke et al, 2014 37	81 patients with cervical (n = 11) and uterine (n = 70) cancer	500 µg of Se on days of RT, 300 µg of Se on days without RT, (form: sodium selenite), n = 39; Placebo, n = 42; Time: 6 weeks	No effect on disease free survival and overall survival; reduced number and severity of RT induced diarrhea

Abbreviations: CIN1, cervical intraepithelial neoplasia 1; RT, radiotherapy.