Table 3.
Cox Regression Models for All-Cause Mortality, AIDS, and Serious Non-AIDS Events by Viremia Category
| Unadjusted Model | Unadjusted Model With Time Interaction | Fully Adjusted Modela | |
|---|---|---|---|
| All-cause mortality, n | 6956 | 6956 | 4541 |
| Virologic suppression | 1 (Ref) | 1 (Ref) | 1 (Ref) |
| LLV of 50–999 copies/mL | 1.7 (1.2–2.4) | 2.6 (1.8–3.7) | 2.2 (1.3–3.6) |
| Nonsuppressed viremia | 2.5 (2.0–3.1) | 6.6 (4.2–10.6) | 7.7 (3.8–15.6) |
| AIDS, n | 6823 | 6823 | 4440 |
| Virologic suppression | 1 (Ref) | 1 (Ref) | 1 (Ref) |
| LLV of 50–999 copies/mL | .45 (.11–1.9) | .84 (.19–3.7) | No event |
| Nonsuppressed viremia | 4.6 (2.9–7.3) | 20.1 (8.3–48.6) | 23.9 (6.3–90.1) |
| Serious non-AIDS events, n | 6884 | 6884 | 4486 |
| Virologic suppression | 1 (Ref) | 1 (Ref) | 1 (Ref) |
| LLV of 50–999 copies/mL | 1.2 (.92–1.6) | 1.6 (1.2–2.2) | 1.2 (.78–1.8) |
| Nonsuppressed viremia | 1.5 (1.3–1.8) | 2.9 (1.9–4.3) | 2.8 (1.6–5.2) |
Values are hazard ratios with 95% confidence intervals.
Abbreviations: ART, antiretroviral therapy; LLV, low-level viremia; Ref, reference; VL, viral load.
aAdjusted for age, sex, CD4 count and VL before start of ART, injection drug use, born in Sweden, treatment experience, and treatment interruptions. Including an interaction term between viremia category and time.