Table 3.
Univariable Logistic Regression Analysis on Diagnostic Performance for Anal Squamous Cell Carcinoma (SCC) Detection (Normal vs SCC) of the 6 Individual Markers (ASCL1, LHX8, SST, WDR17, ZIC1, ZNF582)
| Methylation Marker | ASCL1 | LHX8 | SST | WDR17 | ZIC1 | ZNF582 |
|---|---|---|---|---|---|---|
| AUC (non-CV) (95% CI) | .96 (.93–.99) | .91 (.85–.98) | .98 (.95–1.00) | .95 (.90–1.00) | .96 (.94–.99) | .99 (.97–1.00) |
| Sensitivity, % | 93 | 77 | 97 | 93 | 93 | 100 |
| Specificity, % | 83 | 96 | 92 | 93 | 90 | 95 |
| Missed SCC | 2 | 7 | 1 | 2 | 2 | 0 |
| AUC (LOOCV) | .95 | .90 | .97 | .94 | .96 | .99 |
| Sensitivity, % | 93 | 77 | 97 | 93 | 90 | 100 |
| Specificity, % | 83 | 96 | 92 | 92 | 92 | 95 |
| Missed SCC | 2 | 7 | 1 | 2 | 3 | 0 |
Non–CV, including 95% CI and LOOCV AUCs, are reported. Sensitivity and specificity are for the Youden index threshold. Endpoint: anal SCC in anal tissue samples of HIV-positive men.
Abbreviations: AUC, area under the receiver operating characteristic curve; CI, confidence interval; HIV, human immunodeficiency virus; LOOCV, leave-one-out cross-validated; non-CV, non–cross-validated.