Table 4.

Logistic Regression Analysis on Diagnostic Performance for AIN3+ Detection: Multivariable Regression for Optimal Marker Panel (ZNF582, ASCL1, SST)

Marker Panel	Non-CV	LOOCV
AUC (95% CI)	.90 (.86–.94)	.89
Sensitivity, %	78	76
Specificity, %	90	90
Missed SCC	0	0

Non–CV, including 95% CI and LOOCV AUCs, are reported. Sensitivity and specificity are for the Youden index threshold. Endpoint: AIN3+ (AIN3 and anal SCC) in anal tissue samples of HIV-positive men.

Abbreviations: AIN3, anal intraepithelial neoplasia (grade 3); AUC, area under the receiver operating characteristic curve; CI, confidence interval; HIV, human immunodeficiency virus; LOOCV, leave-one-out cross-validated; non-CV, non–cross-validated; SCC, anal squamous cell carcinoma.