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. 2021 May 27;4(3):1136–1148. doi: 10.1021/acsptsci.1c00033

Figure 2.

Figure 2

Inhibitors specific to HDACs 1, 2, and 3 increased cholesterol clearance in NPC1I1061T fibroblasts. (A) Inhibitors of HDACs 1, 2, and 3 dose-dependently increase cholesterol clearance similar to SAHA. N = 3 independent cell culture experiments. Bars are SEM. ***, P < 0.001; **, P < 0.005. (B) Compounds that do not inhibit HDACs (negative controls) do not increase cholesterol clearance in treated cells. N = 3 independent cell culture experiments. Bars are SEM. (C) Structures of HDAC inhibitors and negative controls.