Figure 5. LEC‐autonomous role of FOXP2 in lymphatic valve morphogenesis.

• A
  Genetic constructs and 4‐OHT treatment for neonatal LEC‐specific Foxp2 deletion. Ex, exon.
• B
  Whole‐mount immunofluorescence of P6 mesenteries, showing valve defects in the mutant vessels.
• C–E
  Quantification of lymphatic valve numbers (C), valve leaflet length (D), and vessel width (E) in Foxp2^{flox / flox};Prox1‐CreER^T2 and littermate control mice (n = vessels (C, E) or valves (D) [mice], as indicated).

Data information: In (C–E), data are presented as mean ± SD. P, Student's t‐test. ns = not significant. Scale bar: 200 µm.

Source data are available online for this figure.