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. 2021 Jun 9;12(7):1102–1107. doi: 10.1021/acsmedchemlett.1c00140

Table 1. Enzymatic Potency against Viral and Human MTases, Cytotoxicity and Cell Permeability of SAM Analogues.

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a

Limit of quantification, 0.2 μM or 1%.

b

Limit of detection.

c

Not determined.

d

Literature IC50 values against SARS-CoV-1 Nsp14 and Nsp16 are 0.112,19 0.383,18 0.4965 μM, and 0.7365 μM, respectively.