Table 3.
Manually curated and annotated reactions in autophagy in Reactome version 71
| Gene Ontology annotations |
||||||
|---|---|---|---|---|---|---|
| Pathways | Total entities* | Total reactions | Cellular components | Molecular functions | Biological processes | Total literature references |
| Macroauto-phagy | 79 | 39 | Cytosol/endosome/lysosome/endoplasmic reticulum/phagophore/autophagosome | kinase/GTPase/phosphatase/transferase/endopeptidase/ligase | Macro- autophagy | 35 |
| Chaperone-mediated autophagy | 27 | 19 | Cytosol/lysosome | - | Chaperone mediated autophagy | 16 |
| Late endosomal microauto- phagy | 5 | 3 | Cytosol/endosome | - | Late endosomal microauto- phagy | 5 |
| Mitophagy | 45 | 15 | Cytosol/mitochondria | Transporter/transferase/kinase/phosphatase | Mitophagy | 17 |
| Lipophagy | 9 | 5 | Cytosol/lipid droplet | - | Lipophagy | 5 |
| Aggrephagy | 26 | 15 | Cytosol/microtubule | - | Aggrephagy | 12 |
*entities include proteins, chemicals, complexes and polymers.