Table 4.
Enriched pathways for top 100 SQSTM1-modulating genes
| Top 100 genes (Low vs High: SQSTM1 degradation) |
Top 100 genes (High vs Low: SQSTM1 accumulation) |
||
|---|---|---|---|
| DeJesus R et al. analysis [19] (GO process) | Reactome analysis (Curated pathway) | DeJesus R et al. analysis [19] (GO process) | Reactome analysis (Curated pathway) |
| transcription initiation from POLR2/RNA polymerase II promoter | autophagy | autophagosome assembly | autophagy |
| gene expression | macroautophagy | macroautophagy | macroautophagy |
| EPH/ephrin receptor signaling pathway | CD28 co-stimulation | mitophagy | nonsense-mediated decay |
| macroautophagy | PPARA activates gene expression | nucleophagy | nonsense-mediated decay enhanced by the exon junction complex |
| regulation of transcription from POLR2/RNA polymerase II promoter | Regulation of lipid metabolism by PPARA/PPARalpha | cellular response to nitrogen starvation | receptor mediated mitophagy |