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. 2021 Jun 14;10(1):1936392. doi: 10.1080/2162402X.2021.1936392

Figure 2.

Figure 2.

Lower modulator effect of KIR2DL2/3 than KIR2DL1, KIR3DL1 and KIR2DS1 on rituximab-dependent NK cell degranulation. RTX-dependent NK cell degranulation (Δ CD107a+) frequency for each targeted NK cell subset: 2DL1− others−, 2DL2/3 others−, 3DL1+ others−, 2DS1+ others− and KIR- NK cells against (a) C1C1 Bw4− EBV-B cell line, (b) C2C2 Bw4− EBV-B cell line, and (c) C2C2 Bw4+ EBV-B cell line. ANOVA test. (d) RTX-dependent NK cell degranulation (Δ CD107a+) frequency following KIR ligands number. The Student’s t-test was performed between the series with three and five KIR ligands. (e) Correlation between percentage of RTX-dependent NK cell degranulation (Δ CD107a+) frequency and the KIR− NK cell frequency. *p < .05, **p < .01, ***p < .005, ****p < .0001