Table 3.

Summarized detailed data of 4× cytokine producers and IL-10 + 3× cytokine producers compared among different age groups

Study/corres-ponding figure	Age group	Abb	Sub group	Median	Upper limit	Lower limit	n	p value
								A vs. C	C vs. N	N vs. A
% of 4x cytokine producers	Adults	A		1.14	5.79	0.51	12	0.008
	Children	C		8.98	12.87	2.37	6		>0.99
	Neonates	N		5.81	57.42	1.03	12			0.015
Dissected 4x cytokine producers	Adults	A	5	1.01	4.63	0.20	12	0.005
	Children	C	5	8.98	12.70	2.37	6		0.893
	Neonates	N	5	4.46	57.20	0.93	12			0.032
% of IL-10 producing 3x cyt. producers	Adults	A		0.49	1.52	0.00	12	0.090
	Children	C		1.56	2.84	0.76	6		0.260
	Neonates	N		0.57	3.08	0.00	12			>0.99
Dissected IL-10 producing 3x cyt. producers	Adults	A	e	0.17	1.16	0.00	12	0.012
	Children	C	e	1.00	2.57	0.76	6		0.076
	Neonates	N	e	0.17	2.60	0.00	12			>0.99

Subgroups 5. IFN-γ (+), IL-17 (+), IL-10 (+), IL-8 (+), IL-4 (-), e. IFN-γ (+), IL-17 (-), IL-10 (+), IL-8 (+), IL-4 (-), n-number of donors, p values obtained from Kruskal-Wallis test followed by Dunn’s multiple comparisons test.